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Applied RNAi: From Fundamental Research to Therapeutic Applications

Applied RNAi: From Fundamental Research to Therapeutic Applications

Since the discovery of RNA interference (RNAi) in 1998, research on the topic has advanced at an impressive pace. Small RNAs, and in particular micro RNAs (miRNAs), play a fundamental role in gene regulation through the activation of RNAi.

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Applied RNAi: From Fundamental Research to Therapeutic Applications
Publisher: Caister Academic Press
Editor: Patrick Arbuthnot1 and Marc S. Weinberg1,2 1Antiviral Gene Therapy Research Unit, School of Pathology, University of the Witwatersrand, WITS 2050, South Africa; 2Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Rd., La Jolla, 92037, USA.
Publication date: June 2014 (hardback); May 2014 (ebook)
Pages:                  252
Hardback:             ISBN 978-1-908230-43-0

Ebook:                   ISBN 978-1-908230-67-6 

Price £159.00

Detailed insights into the mechanisms of RNAi have led to an improved understanding of gene regulation in normal and disease states, and thereby enabled the exploitation of RNAi for a variety of applications.

In this book an international panel of RNAi experts critically reviews the most interesting advances in basic applied RNAi research, highlighting the applications in RNAi-based therapies and discussing the technical hurdles that remain. Topics covering the fundamental biological aspects of applied RNAi research include: the role of miRNAs in trinucleotide repeat disorders; miRNAs and HIV pathogenesis; miRNAs for epigenetic gene silencing; the role of miRNAs in virus-related cancers; non-canonical miRNA biogenesis. In the area of RNAi-based therapy, topics include: harnessing RNAi for the treatment of viral infections; optimising the design of exogenous RNAi activators; blocking miRNA function with synthetic agents; somatic cell reprogramming; high-content miRNA-based screening tools and the use of miRNA target sites for control of transgene expression.

Essential reading for everyone involved in RNAi research, drug discovery and delivery, biomedical engineering and biomaterials.



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